Secondary auditory cortex function12/3/2023 ![]() These simple yet clear results suggested that in sound cued fear conditioning, sound cue and detailed content in the cue (e.g., frequency) are processed through distinct neural circuits and AAF is a critical part in the cortex dependent pathway. Reversible inhibition of AAF using chemogenetic activation at either training or testing phase can both lead to strong yet non-selective sound cued freezing behavior. Precise surgical ablation of AAF cannot block sound cued freezing behavior but the fear conditioning became non-selective to acoustic cue. Here in adult rats, sound cued fear conditioning paradigm, surgical ablation, and chemogenetic manipulations were used to examine the role of AAF in fear related sound context recognition. While the function of A1 has been well documented, the role of AAF in sound related behavioral remain largely unclear. 2Department of Materials Science, Chongqing University of Science and Technology, Chongqing, Chinaīoth primary auditory cortex (A1) and anterior auditory field (AAF) are core regions of auditory cortex of many mammalians. ![]() 1Department of Neurobiology, School of Basic Medical Sciences, Army Medical University, Chongqing, China.Zhiyue Shi 1 Sumei Yan 1 Yu Ding 1 Chang Zhou 1 Shaowen Qian 1 Zhaoqun Wang 1 Chen Gong 2 Meng Zhang 2 Yanjie Zhang 2 Yandong Zhao 1 Huizhong Wen 1 Penghui Chen 1 Qiyue Deng 1 Tiantian Luo 1 Ying Xiong 1* Yi Zhou 1* ![]()
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